CHRONIC RENAL MAGNESIUM LOSS, HYPOCALCIURIA AND MILD HYPOKALEMIC METABOLIC ALKALOSIS AFTER CISPLATIN

被引：36

作者：

BIANCHETTI, MG ^{[1
]}

KANAKA, C ^{[1
]}

RIDOLFILUTHY, A ^{[1
]}

WAGNER, HP ^{[1
]}

HIRT, A ^{[1
]}

PAUNIER, L ^{[1
]}

PEHEIM, E ^{[1
]}

OETLIKER, OH ^{[1
]}

机构：

[1] UNIV BERN,CHILDRENS HOSP,DIV NEPHROL,CH-3010 BERN,SWITZERLAND

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 03期

关键词：

Bartter's syndrome; Cisplatin nephropathy; Gitelman's syndrome; Hypocalciuria; Hypokalaemia with hypocalciuria; primary renotubular hypomagnesaemia; Renal magnesium wasting;

D O I：

10.1007/BF00857658

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Renotubular handling of sodium, potassium (K) calcium (Ca), phosphate, hydrogen ions and glucose, and urinary concentrating ability were studied in three children (aged 8, 8.5, 11 years) with renal magnesium (Mg) loss, persisting for more than 2 years after discontinuation of cisplatin treatment for neuroblastoma. A group of healthy children served as controls. Besides renal Mg wasting, a clear-cut tendency towards reduced calciuria associated with normal or slightly elevated plasma Ca was observed. Plasma K tended to be low (3.4-3.7 mmol/l), and plasma chloride was normal. Plasma bicarbonate (HCO3) ranged from 24.9 to 27.8 mmol/l, and urinary pH was always less than 6.0, indicating a renal HCO3 threshold exceeding 24 mmol/l. Plasma creatinine levels, glucosuria and phosphaturia, and urinary concentrating capacity were adequate. Comparable features were found in three children (aged 4.5, 9, 13 years) with primary renotubular hypomagnesaemia - hypokalaemia and hypocalciuria. This study complements the picture of chronic cisplatin tubulopathy in childhood demonstrating that, apart from Mg wasting, a reduced Ca excretion, and a tendency to hypokalaemia and metabolic alkalosis exist. Thus cisplatin may induce renal functional damage identical to that found in primary renotubular hypomagnesaemia - hypokalaemia with hypocalciuria. © 1990 IPNA.

引用

页码：219 / 222

页数：4

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