IMMUNOHISTOLOGICAL DETECTION OF BOVINE VIRAL DIARRHEA VIRUS-ANTIGEN IN THE CENTRAL-NERVOUS-SYSTEM OF PERSISTENTLY INFECTED CATTLE USING MONOCLONAL-ANTIBODIES

被引：31

作者：

HEWICKER, M

WOHRMANN, T

FERNANDEZ, A

TRAUTWEIN, G

LIESS, B

MOENNIG, V

机构：

[1] TIERARZTL HSCH HANOVER,DEPT PATHOL,BISCHOFSHOLER DAMM 15,W-3000 HANOVER 1,GERMANY

[2] TIERARZTL HSCH HANOVER,DEPT VIROL,W-3000 HANOVER 1,GERMANY

来源：

VETERINARY MICROBIOLOGY | 1990年 / 23卷 / 1-4期

关键词：

D O I：

10.1016/0378-1135(90)90150-T

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a total of 25 cattle persistently infected with bovine viral diarrhoea virus (BVDV) the distribution of viral antigens in the central nervous system was studied. Using a panel of monoclonal antibodies (anti pestivirus C16; anti cytophathic BVDV C38; anti cytopathic and non-cytopathic BVDV C42; anti gp53 BVDV CA-1 and CA-3) and the indirect immunoperoxidase technique, BVDV antigen was located exclusively in neurons. Predilection sites for viral persistence were cerebral cortex and hippocampus. Morphological cellular alterations were not seen. Reactive perivascular lymphocytic infiltrations were occasional findings. © 1990.

引用

页码：203 / 210

页数：8

共 19 条

[1]

BAKER J, 1987, J AM VET MED ASSOC, V190, P242

[2] RECENT ADVANCES IN PESTIVIRUS RESEARCH [J].

COLLETT, MS ;

MOENNIG, V ;

HORZINEK, MC .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :253-266

[3]

CORIA MF, 1978, J AM VET MED ASSOC, V172, P449

[4]

CUTLIP RC, 1980, AM J VET RES, V41, P1938

[5] VIRAL-ANTIGEN DISTRIBUTION IN THE CENTRAL NERVOUS-SYSTEM OF CATTLE PERSISTENTLY INFECTED WITH BOVINE VIRAL DIARRHEA VIRUS [J].

FERNANDEZ, A ;

HEWICKER, M ;

TRAUTWEIN, G ;

POHLENZ, J ;

LIESS, B .

VETERINARY PATHOLOGY, 1989, 26 (01) :26-32

[6]

LIESS B, 1984, ZBL VET MED B, V31, P669

[7]

LIESS B, 1987, DEUT TIERARZTL WOCH, V94, P583

[8]

LIESS B, 1983, DEUT TIERARZTL WOCH, V90, P261

[9]

MATEO A, 1988, THESIS SCH VET MED H

[10]

MCCLURKIN AW, 1984, CAN J COMP MED, V48, P156

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