IMMUNOREACTIVE INTERLEUKIN-1-BETA LOCALIZATION IN THE RAT FOREBRAIN

被引：352

作者：

LECHAN, RM

TONI, R

CLARK, BD

CANNON, JG

SHAW, AR

DINARELLO, CA

REICHLIN, S

机构：

[1] NEW ENGLAND MED CTR,DIV INFECT DIS,BOSTON,MA 02111

[2] GLAXO INST MOLEC BIOL,GENEVA,SWITZERLAND

来源：

BRAIN RESEARCH | 1990年 / 514卷 / 01期

关键词：

Cytokine; Hippocampus; Hypothalamus; Immunocytochemistry; Interleukin-1; Olfactory tubercle;

D O I：

10.1016/0006-8993(90)90445-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions. © 1990.

引用

页码：135 / 140

页数：6

共 39 条

[1] CORTICOTROPIN-RELEASING FACTOR PRODUCING NEURONS IN THE RAT ACTIVATED BY INTERLEUKIN-1 [J].