ALZHEIMERS-DISEASE - BETA-AMYLOID PRECURSOR PROTEIN MESSENGER-RNA EXPRESSION IN MONONUCLEAR BLOOD-CELLS

被引：23

作者：

ALLEN, JS

MURPHY, GM

ENG, LF

STULTZ, KE

DAVIES, HD

PICKFORD, LB

TINKLENBERG, JR

机构：

[1] VET AFFAIRS MED CTR,PSYCHIAT SERV 116A3,PALO ALTO,CA 94304

[2] STANFORD UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,PALO ALTO,CA 94304

[3] STANFORD UNIV,SCH MED,DEPT PATHOL,PALO ALTO,CA 94304

来源：

NEUROSCIENCE LETTERS | 1991年 / 132卷 / 01期

关键词：

ALZHEIMERS DISEASE; MONOCYTE; LYMPHOCYTE; BETA-AMYLOID PRECURSOR PROTEIN; POLYMERASE CHAIN REACTION;

D O I：

10.1016/0304-3940(91)90445-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Beta-amyloid precursor protein (beta-APP) mRNA was examined in peripheral mononuclear blood cells (PMBCs) in Alzheimer's disease, Down's syndrome and control subjects. Total RNA from PMBCs was reverse transcribed and then amplified using the polymerase chain reaction (PCR). The 3 major beta-APP transcripts were expressed in PMBCs from all subjects. The results suggest that PMBCS could be a circulating source for abnormal amyloid deposition in the brain and in peripheral tissues.

引用

页码：109 / 112

页数：4

共 25 条

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