NUCLEOSIDES AND NUCLEOTIDES .92. SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF 3'-DEOXY-3'-ISOCYANO-THYMIDINES, 3'-DEOXY-3'-ISOTHIOCYANO-THYMIDINES, AND 3'-DEOXY-3'-ISOSELENOCYANO-THYMIDINES

被引：17

作者：

MATSUDA, A

SATOH, M

UEDA, T

MACHIDA, H

SASAKI, T

机构：

[1] YAMASA SHOYU CO LTD,RES LABS,CHOSHI 288,JAPAN

[2] KANAZAWA UNIV,CANC RES INST,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1990年 / 9卷 / 04期

关键词：

D O I：

10.1080/07328319008045190

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2'.3'-Dideoxv-3'-isothiocvano, -isocyano. and -isoseleno- cyanothymidines (6b, 8b, and 9) were synthesized from the corresponding 3’-amino derivatives (5a, b). These nucleosides were tested for inhibitory activity of the pathogenicity of HIV-1 and the growth inhibitory activity of mouse and human cancer cell lines. © 1990, Taylor & Francis Group, LLC. All rights reserved.

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页码：587 / 597

页数：11

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