FUNCTIONALIZED OXOVANADIUM ALKOXIDES - POTENTIAL HAPTENS

Several new oxovanadium alkoxides and alkoxides/chlorides of the composition VOCl3-n(OR)n (n = 1, R = CPh3; n = 2 and 3, R = CPh3, iBu, cyclopentyl, tert-pentyl, octyl; n = 3, R = dodecyl, 3-methylbutyl) and the mixed ester VO(OiBu)-(OCPh3)2 have been prepared. The compounds VO(OiBu)2OR' have been synthesized, where R' is a functionalized long-chain alkyl group [-(CH2)8OH, -(CH2)6NH(FMOC), -(CH2)6NH2, -C(O)(CH2)5C(O)OMe, p-C6H4CN, p-C6H4NH2]. The chloride/carboxylate VOCl2{O2C(CH2)5CO2H} has also been obtained. The compounds are characterized, inter alia, by V-51-NMR spectroscopy. Typical V-51 shift ranges are observed for specific ligand functionalities (chloride, alkoxide, carboxylate). delta(V-51) values also depend on the steric requirement of the groups R and the coordination number. The importance of the functionalized esters as potential triggers for the production of abzymes with phosphatase activity is discussed.