PRONUCLEAR, CLEAVAGE AND BLASTOCYST HISTORIES IN THE ATTEMPTED PREIMPLANTATION DIAGNOSIS OF THE HUMAN HYDATIDIFORM MOLE

被引：24

作者：

EDWARDS, RG ^{[1
]}

CROW, J ^{[1
]}

DALE, S ^{[1
]}

MACNAMEE, MC ^{[1
]}

HARTSHORNE, GM ^{[1
]}

BRINSDEN, P ^{[1
]}

机构：

[1] CHURCHILL COLL,CAMBRIDGE CB3 9EU,ENGLAND

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 07期

关键词：

PREIMPLANTATION DIAGNOSIS; HYDATIDIFORM MOLE; SYNGAMY; PRONUCLEI; ANDROGENESIS;

D O I：

10.1093/oxfordjournals.humrep.a137787

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We report a study of fertilization, syngamy and embryonic development in 14 oocytes from a woman with four previous pregnancies involving complete hydatidiform moles. Serial observations of pronuclear movements and syngamy were compared to those in a group of 10 multipronucleate embryos from other patients. One embryo and possibly two others developed normally or near-normally. The others displayed immediate cleavage or had one or three pronuclei. The tripronucleate eggs displayed various anomalous forms of growth. The unipronucleate eggs passed through a double form of syngamy, which might have involved chromosome doubting, and could have developed as androgenetic diploids. We suggest a hypothesis to explain these unusual observations.

引用

页码：994 / 998

页数：5

共 18 条

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