RELEASE OF VASOACTIVE SUBSTANCES DURING CARDIOPULMONARY BYPASS

被引:260
作者
DOWNING, SW [1 ]
EDMUNDS, LH [1 ]
机构
[1] UNIV PENN,SCH MED,DEPT SURG,DIV CARDIOTHORAC SURG,PHILADELPHIA,PA 19104
关键词
D O I
10.1016/0003-4975(92)90113-I
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiopulmonary bypass is associated with bleeding and thrombotic complications, massive fluid shifts, and cellular and hormonal defense reactions that are collectively termed "the whole body inflammatory response." A host of vasoactive substances are produced, released or altered during cardiopulmonary bypass. These hormones, autacoids, and cytokines react with specific receptor proteins distributed throughout the body, and mediate the vascular smooth muscle and endothelial cell contractions that are responsible for much of the morbidity associated with open heart operations. This essay briefly reviews the actions, sources, and perturbations of the approximately 25 vasoactive substances known or believed to be altered by cardiopulmonary bypass, and provides an introductory reference list.
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页码:1236 / 1243
页数:8
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