THE ECITTS INTEGRATED TOXICITY TESTING SCHEME - THE APPLICATION OF IN-VITRO TEST SYSTEMS TO THE HAZARD ASSESSMENT OF CHEMICALS

被引：13

作者：

BLAAUBOER, BJ

BALLS, M

BIANCHI, V

BOLCSFOLDI, G

GUILLOUZO, A

MOORE, GA

ODLAND, L

REINHARDT, CA

SPIELMANN, H

WALUM, E

机构：

[1] ERGATT, Secretariat: Research Institute of Toxicology, Utrecht University, 3508 TD Utrecht

来源：

TOXICOLOGY IN VITRO | 1994年 / 8卷 / 04期

关键词：

D O I：

10.1016/0887-2333(94)90083-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A multicentre project has been designed, with the purpose of developing the concept of integrated in vitro testing. The aim is to use non-animal methods to assess the toxicological properties of chemicals, and to improve this assessment through the use of knowledge of mechanisms of toxic action. A number of tests or test batteries were selected within eight areas: basal cytotoxicity, irritancy, developmental toxicology, hepatotoxicity, nephrotoxicity, immunotoxicity, neurotoxicity and biokinetics. For each area, a number of calibration chemicals were selected. In an initial pilot study, the neurotoxic properties of five chemicals will be studied in combination with a biokinetic analysis, in which blood and brain concentrations will be predicted from biokinetic modelling.

引用

页码：845 / 846

页数：2