CHEMICALLY MODIFIED POLYMERIC RESINS FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Chemical reactions were used to attach various hydrophilic functional groups and one hydrophobic group to cross-linked polystyrene resins. Those with hydrophilic groups had much better wettability by water. The capacity factors of a number of test compounds were compared on columns packed with derivatized and underivatized polymeric resins. The capacity factor of most test compounds were distinctly different on columns packed with the derivatized resins. In some cases the elution order of test compounds was different on the derivatized resin columns. The modified resins offer an additional selectivity parameter for liquid chromatographic separations. © 1990.