RECEPTOR-MEDIATED CHANGES IN INTRACELLULAR [CA2+] IN CULTURED RAT-BRAIN CAPILLARY ENDOTHELIAL-CELLS

被引：56

作者：

REVEST, PA ^{[1
]}

ABBOTT, NJ ^{[1
]}

GILLESPIE, JI ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT PHYSIOL SCI,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

来源：

BRAIN RESEARCH | 1991年 / 549卷 / 01期

基金：

英国医学研究理事会;

关键词：

ENDOTHELIAL CELL; BLOOD BRAIN BARRIER; FURA-2; CALCIUM;

D O I：

10.1016/0006-8993(91)90614-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Agents which are known to alter blood-brain barrier permeability have been tested for their ability to raise [Ca2+]i in rat brain capillary endothelial cells loaded with the calcium indicator Fura-2, and subjected to dual wavelength excitation. The cells show increases in [Ca2+]i in response to bradykinin, histamine and ATP. Possible sources of this calcium are discussed.

引用

页码：159 / 161

页数：3

共 9 条

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