EFFECTS OF OMEGA-3, OMEGA-6 AND OMEGA-9 FATTY-ACIDS ON VASCULAR SMOOTH-MUSCLE TONE

被引：28

作者：

ENGLER, MB

机构：

[1] Laboratory of Cardiovascular Physiology, Department of Physiological Nursing, University of California at San Francisco, San Francisco, CA 94143-0610

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期

关键词：

DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; FATTY ACIDS (OMEGA-3; OMEGA-6; OMEGA-9); FISH OIL;

D O I：

10.1016/0014-2999(92)90050-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The comparative effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone were investigated. Docosahexaenoic acid (1-255-mu-M) and eicosapentaenoic acid (31-255-mu-M) inhibited phenylephrine-induced contractions, (8-63%) and (20-65%), respectively, which were not altered by indomethacin, NDGA, or by removal of the endothelium. Linoleic acid (18:2n6) and arachidonic acid (20:4n6) also induced significant relaxation. Therefore, fatty acid-induced relaxation of the rat aorta is specific to polyunsaturated fatty acids, 20:5n3, 22:6n3, 18:2n6 and 20:4n6.

引用

页码：325 / 328

页数：4

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