KARYOTYPIC ANALYSIS OF GASTRIC-CARCINOMA CELL-LINES CARRYING AN AMPLIFIED C-MET ONCOGENE

被引:64
作者
REGECAMBRIN, G
SCARAVAGLIO, P
CAROZZI, F
GIORDANO, S
PONZETTO, C
COMOGLIO, PM
SAGLIO, G
机构
[1] UNIV PERUGIA,MED CLIN 1,I-06100 PERUGIA,ITALY
[2] CNR,CTR IMMUNOGENET & HISTOCOMPATIBIL,TURIN,ITALY
关键词
D O I
10.1016/0165-4608(92)90350-H
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MKN 45 is a poorly differentiated gastric carcinoma cell line from which the subclone GTL 16 was obtained. Both lines carry an amplification unit derived from chromosome 7 sequences and containing an activated c-met oncogene. Karotypic analysis showed that GTL 16 derived from a subclone of MKN 45 after endoreduplication. Several clonal abnormalities are evident in both lines; some are frequently observed in gastrointestinal tumors (loss of 17p and monosomy 18). Other consistent anomalies include 6q-, t(8;10) and t(5;8), and inv(16). A marker chromosome ((M1), which was previously shown to contain the c-met amplification unit, is constantly duplicated in all GTL 16 metaphases; in contrast, most unidentified markers are retained in only a single copy in GTL 16 cells. These data are in agreement with the hypothesis that the c-met oncogene activation in these gastric cancer cell lines might be related to a gene dosage effect.
引用
收藏
页码:170 / 173
页数:4
相关论文
共 14 条
[1]   ISOCHROMOSOME-8Q - A RECURRENT CHANGE IN GASTRIC-CARCINOMA [J].
CASTEDO, S ;
CORREIA, C ;
DAVID, L ;
SOBRINHOSIMOES, M .
CANCER GENETICS AND CYTOGENETICS, 1991, 54 (01) :137-138
[2]   COMMON CYTOGENETIC FINDINGS IN GASTRIC-CANCER [J].
FERTIPASSANTONOPOULOU, AD ;
PANANI, AD ;
VLACHOS, JD ;
RAPTIS, SA .
CANCER GENETICS AND CYTOGENETICS, 1987, 24 (01) :63-73
[3]   TYROSINE KINASE RECEPTOR INDISTINGUISHABLE FROM THE C-MET PROTEIN [J].
GIORDANO, S ;
PONZETTO, C ;
DIRENZO, MF ;
COOPER, CS ;
COMOGLIO, PM .
NATURE, 1989, 339 (6220) :155-156
[4]   ASSOCIATION OF AN INVERSION OF CHROMOSOME-16 WITH ABNORMAL MARROW EOSINOPHILS IN ACUTE MYELOMONOCYTIC LEUKEMIA - A UNIQUE CYTOGENETIC CLINICOPATHOLOGICAL ASSOCIATION [J].
LEBEAU, MM ;
LARSON, RA ;
BITTER, MA ;
VARDIMAN, JW ;
GOLOMB, HM ;
ROWLEY, JD .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (11) :630-636
[5]  
MITELMAN F, 1988, CATALOG CHROMOSOME A
[6]  
MOTOYAMA T, 1986, ACTA PATHOL JAPON, V36, P65
[7]   CYTOGENETIC AND MOLECULAR APPROACHES OF POLYPLOIDIZATION IN COLORECTAL ADENOCARCINOMAS [J].
MULERIS, M ;
DELATTRE, O ;
OLSCHWANG, S ;
DUTRILLAUX, AM ;
REMVIKOS, Y ;
SALMON, RJ ;
THOMAS, G ;
DUTRILLAUX, B .
CANCER GENETICS AND CYTOGENETICS, 1990, 44 (01) :107-118
[8]   MUTATIONS IN THE P53 GENE OCCUR IN DIVERSE HUMAN-TUMOR TYPES [J].
NIGRO, JM ;
BAKER, SJ ;
PREISINGER, AC ;
JESSUP, JM ;
HOSTETTER, R ;
CLEARY, K ;
BIGNER, SH ;
DAVIDSON, N ;
BAYLIN, S ;
DEVILEE, P ;
GLOVER, T ;
COLLINS, FS ;
WESTON, A ;
MODALI, R ;
HARRIS, CC ;
VOGELSTEIN, B .
NATURE, 1989, 342 (6250) :705-708
[9]   CYTOGENETIC STUDIES IN PRIMARY GASTRIC-CANCER [J].
OCHI, H ;
DOUGLASS, HO ;
SANDBERG, AA .
CANCER GENETICS AND CYTOGENETICS, 1986, 22 (04) :295-307
[10]  
PONZETTO C, 1991, ONCOGENE, V6, P553