EFFECTS OF BROMOCRIPTINE ON CENTRAL DOPAMINERGIC RECEPTORS

被引：95

作者：

TRABUCCHI, M

SPANO, PF

TONON, GC

FRATTOLA, L

机构：

[1] UNIV MILAN, DEPT NEUROL, I-20133 MILAN, ITALY

[2] UNIV BRESCIA, DEPT PHARMACOL, BRESCIA, ITALY

来源：

LIFE SCIENCES | 1976年 / 19卷 / 02期

关键词：

D O I：

10.1016/0024-3205(76)90394-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bromocriptine injected into rats increases c[cyclic]AMP levels in the striatum in vivo. The time course of this increase is very similar to that of apomorphine. Bromocriptine did not stimulate striatal dopamine-sensitive adenylate cyclase but antagonized the activation of this enzyme elicited by dopamine. Possible hypotheses on various sites of action are discussed.

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页码：225 / 231

页数：7

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