A GENETIC-POLYMORPHISM IN A FUNCTIONAL DOMAIN OF HUMAN-PREGNANCY ZONE PROTEIN - THE BAIT REGION - GENOMIC STRUCTURE OF THE BAIT DOMAINS OF HUMAN-PREGNANCY ZONE PROTEIN AND ALPHA-2 MACROGLOBULIN

被引：12

作者：

MARYNEN, P

DEVRIENDT, K

VANDENBERGHE, H

CASSIMAN, JJ

机构：

[1] Center for Human Genetics, University of Leuven, B-3000 Leuven, Campus Gasthuisberg

来源：

FEBS LETTERS | 1990年 / 262卷 / 02期

关键词：

Macroglobulin; α; Proteinase inhibitor;

D O I：

10.1016/0014-5793(90)80226-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic clones containing the exons coding for the bait domain of human pregnancy zone protein and α2 macroglobulin were isolated and fragments containing the bait exons were sequenced. It is shown that the bait domains of both α2 macroglobulin and pregnancy zone protein are encoded by two exons, with conserved exon/intron boundaries. A genetic polymorphism showing either a Met or a Val residue as the sixth amino acid of the pregnancy zone protein bait domain was detected with the rare Met allele showing a gene frequency of 0.065. © 1990.

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页码：349 / 352

页数：4

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