INDOLINONIC AND QUINOLINIC AMINOXYLS AS PROTECTANTS AGAINST OXIDATIVE STRESS

被引：31

作者：

ANTOSIEWICZ, J

BERTOLI, E

DAMIANI, E

GRECI, L

POPINIGIS, J

PRZYBYLSKI, S

TANFANI, F

WOZNIAK, M

机构：

[1] UNIV ANCONA,DIPARTIMENTO SCI MAT & TERRA,VIA BRECCE BIANCHE,I-60131 ANCONA,ITALY

[2] ACAD PHYS EDUC GDANSK,DEPT BIOENERGET,GDANSK,POLAND

[3] MED ACAD GDANSK,DEPT BIOCHEM,PL-80416 GDANSK,POLAND

[4] UNIV ANCONA,INST BIOCHEM,I-60131 ANCONA,ITALY

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1993年 / 15卷 / 02期

关键词：

LIPID PEROXIDATION; INDOLINONIC AMINOXYLS; QUINOLINIC AMINOXYLS; ANTIOXIDANTS; FREE RADICALS;

D O I：

10.1016/0891-5849(93)90060-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study on thermally and peroxyl radical induced oxidation of linolenic acid micelles in the presence of different concentrations of aminoxyls was carried out in order to test their efficiency as antioxidants in lipid peroxidation. The extent of peroxidation was measured by the malondialdehyde (MDA) produced and by oxygen consumption evaluated using an oxygraph. The results obtained indicate that indolinonic and quinolinic aminoxyls synthesized by us could be used as effective antioxidants in biological systems.

引用

页码：203 / 208

页数：6

共 30 条

[1]

BAST A, 1991, AM J MED, V91, pC3

[2] KINETICS OF THE COUPLING REACTIONS OF THE NITROXYL RADICAL 1,1,3,3-TETRAMETHYLISOINDOLINE-2-OXYL WITH CARBON-CENTERED RADICALS [J].