THE OTOTOXIC MECHANISM OF CISPLATIN

被引：91

作者：

MCALPINE, D ^{[1
]}

JOHNSTONE, BM ^{[1
]}

机构：

[1] UNIV WESTERN AUSTRALIA, DEPT PHYSIOL, NEDLANDS, WA 6009, AUSTRALIA

来源：

HEARING RESEARCH | 1990年 / 47卷 / 03期

关键词：

Cisplatin; Cochlear microphonic; Distortion products; Potentiation;

D O I：

10.1016/0378-5955(90)90151-E

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The ototoxic mechanism of cisplatin was investigated. Potentiation of cisplatin ototoxicity by furosemide and amino-oxyacetic acid (AOAA) was observed. Substantial hearing loss in cisplatin-deafened animals was accompanied by normal values of the endocochlear potential and a reduction in the sensitivity of the 2f1-f2 distortion products. The loss in dB of the sensitivity of the distortion products correlated extremely well with the loss of the neural sensitivity in dB. There was also a relationship between the fractional reduction of the low frequency (1000 Hz) microphonic potential and hearing loss in dB. Iontophoresis of cisplatin into scala media resulting in the immediate loss of neural thresholds at the site of iontophoresis. It is concluded that cisplatin caused the hearing loss by blocking OHC transduction channels. © 1990.

引用

页码：191 / 204

页数：14

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