INTERFERON SUPPRESSES SYMPATHETIC NEURONAL CELL-DEATH CAUSED BY NERVE GROWTH-FACTOR DEPRIVATION

被引：83

作者：

CHANG, JY ^{[1
]}

MARTIN, DP ^{[1
]}

JOHNSON, EM ^{[1
]}

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT PHARMACOL, 660 S EUCLID AVE, ST LOUIS, MO 63110 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 02期

关键词：

Interferons; Nerve growth factor; Neuronal cell death; Superior cervical ganglion;

D O I：

10.1111/j.1471-4159.1990.tb04155.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cultured rat sympathetic neurons die within 48 h after being deprived of nerve growth factor. Addition of interferons (IFN‐α/β or IFN‐γ) prevented the cell death in a dose‐dependent manner. Upon longer periods of nerve growth factor deprivation, IFNs failed to maintain survival. Thus, IFNs retarded neuronal death, but did not prevent it. Ligand binding, autoradiography, and cross‐linking experiments demonstrated the presence of specific IFN‐γ receptors on sympathetic neurons similar to those seen on other cell types. The possible relationships of the death‐suppressing actions of IFNs are compared to the mechanisms of the antiviral or antiproliferative actions of IFNs. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：436 / 445

页数：10

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