CHEMICAL STUDIES ON SOPHORA-TOMENTOSA - THE ISOLATION OF A NEW CLASS OF ISOFLAVONOID

被引：49

作者：

KINOSHITA, T

ICHINOSE, K

TAKAHASHI, C

HO, FC

WU, JB

SANKAWA, U

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, TOKYO 113, JAPAN

[2] TAIWAN FORESTRY RES INST, HENGCHUAN, TAIWAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 10期

关键词：

isoflavonoid; Keywords; 6-methoxypterocarpan; Leguminosae; Sophora tomentosa; sophoracarpan A; sophoracarpan B; stereochemistry;

D O I：

10.1248/cpb.38.2756

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new pterocarpans, sophoracarpans A and B, were isolated from Sophora tomentosa L. (Leguminosae) in addition to three known isoflavonoids, wighteone (erythrinin B), sophoraisoflavanone A and /-maackiain. The structures of sophoracarpans A and B were elucidated as 6/?,9-dimethoxy-3-hydroxypterocarpan and 3-hydroxy-6/J-methoxy-8,9-methylenedioxypterocarpan, respectively, on the spectroscopic basis. The configurations at C-6, C-6a, and C-lla of both compounds were determined by a series of nuclear magnetic resonance irradiation experiments. The isoflavone wighteone, known as an antifungal phytoalexin in several genera of leguminous plants, was also found to occur in the genus Sophora. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2756 / 2759

页数：4

共 18 条

[1] FLAVONOIDS FROM MILLETTIA-PULCHRA [J].

BARUAH, P ;

BARUA, NC ;

SHARMA, RP ;

BARUAH, JN ;

KULANTHAIVEL, P ;

HERZ, W .

PHYTOCHEMISTRY, 1984, 23 (02) :443-447

[2] C-13 NMR OF PTEROCARPANS [J].

CHALMERS, AA ;

RALL, GJH ;

OBERHOLZER, ME .

TETRAHEDRON, 1977, 33 (14) :1735-1737

[3]

DESHPANDE VH, 1977, INDIAN J CHEM B, V15, P205

[4]

DEWICK PM, 1982, FLAVONOID ADV RES, pCH10

[5] ISOFLAVONOIDS OF YELLOW LUPIN .1. NEW COMPLEX ISOFLAVONES IN THE ROOTS OF YELLOW LUPIN (LUPINUS-LUTEUS L, CV BARPINE) [J].

HASHIDOKO, Y ;

TAHARA, S ;

MIZUTANI, J .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1986, 50 (07) :1797-1807

[6]

INGHAM JL, 1983, Z NATURFORSCH C, V38, P194

[7] NEW ISOFLAVONE PHYTOALEXIN FROM FUNGUS-INOCULATED STEMS OF GLYCINE-WIGHTII [J].

INGHAM, JL ;

KEEN, NT ;

HYMOWITZ, T .

PHYTOCHEMISTRY, 1977, 16 (12) :1943-1946

[8]

INGHAM JL, 1983, PROGR CHEM ORGANIC N, P71

[9]

KINOSHITA T, 1986, CHEM PHARM BULL, V34, P3067

[10]

KOMATSU M, 1978, CHEM PHARM BULL, V26, P1274

← 1 2 →