BREAKDOWN OF THE BLOOD-BRAIN-BARRIER PRECEDES SYMPTOMS AND OTHER MRI SIGNS OF NEW LESIONS IN MULTIPLE-SCLEROSIS - PATHOGENETIC AND CLINICAL IMPLICATIONS

被引：504

作者：

KERMODE, AG ^{[1
]}

THOMPSON, AJ ^{[1
]}

TOFTS, P ^{[1
]}

MACMANUS, DG ^{[1
]}

KENDALL, BE ^{[1
]}

KINGSLEY, DPE ^{[1
]}

MOSELEY, IF ^{[1
]}

RUDGE, P ^{[1
]}

MCDONALD, WI ^{[1
]}

机构：

[1] NATL HOSP, LONDON WC1N 3BG, ENGLAND

来源：

BRAIN | 1990年 / 113卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/brain/113.5.1477

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This supports the view that a defect in the blood-brain barrier, and therefore inflammation, is an early and possibly crucial event in the pathogenesis of the new lesion in MS. These cases showed a marked discrepancy between MRI abnormality and symptoms. The mechanisms contributing to this disparity are discussed, and it is concluded that far from being surprising it is to be expected. © 1990 Oxford University Press.

引用

页码：1477 / 1489

页数：13

共 38 条

[1] ONSET AND PROGRESSION OF LESION IN MULTIPLE-SCLEROSIS [J].