SYNTHESIS OF AN INHIBITOR OF SPHINGOSINE-1-PHOSPHATE LYASE

被引：15

作者：

BOUMENDJEL, A

MILLER, SPF

机构：

[1] National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)75971-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 2-vinyl dihydrosphingosine-1-phosphate 1 was synthesized and tested for inhibition of sphingosine-l-phosphate lyase. The carbon skeleton was prepared by acylation of a methionine imine with N-methoxy-N-methyl palmitamide. The vinyl group was generated by thermal sulfoxide elimination. Reduction of both carbonyl groups and deprotection gave 2-vinyl dihydrosphingosine. The phosphate group was introduced by means of bis(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite as monofunctional phosphitylation reagent.

引用

页码：819 / 822

页数：4

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