CLINICAL IMPLICATIONS OF THE P53 TUMOR-SUPPRESSOR GENE

被引：1340

作者：

HARRIS, CC ^{[1
]}

HOLLSTEIN, M ^{[1
]}

机构：

[1] INT AGCY RES CANC, WHO, MECHANISMS CARCINOGENESIS UNIT, F-69372 LYON, FRANCE

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1993年 / 329卷 / 18期

关键词：

D O I：

10.1056/NEJM199310283291807

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The crucial differences between normal cells and cancer cells stem from discrete changes in specific genes controlling proliferation and tissue homeostasis. Over 100 such cancer-related genes have been discovered, several of which are implicated in the natural history of human cancer because they are consistently found to be mutated in tumors. The p53 tumor-suppressor gene is the most striking example because it is mutated in about half of almost all types of cancer arising from a wide spectrum of tissues. Other tumor-suppressor genes important in human cancers, such as adenomatous polyposis coli, Wilms' tumor type 1, and neurofibromatosis type 1,… © 1993, Massachusetts Medical Society. All rights reserved.

引用

页码：1318 / 1327

页数：10

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