T-CELL DYSFUNCTION IN HIV-INFECTION - ANERGY DUE TO DEFECTIVE ANTIGEN-PRESENTING CELL-FUNCTION

被引：175

作者：

MEYAARD, L ^{[1
]}

SCHUITEMAKER, H ^{[1
]}

MIEDEMA, F ^{[1
]}

机构：

[1] UNIV AMSTERDAM, EXPTL & CLIN IMMUNOL LAB, AMSTERDAM, NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 04期

关键词：

D O I：

10.1016/0167-5699(93)90279-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Before CD4+ T cells are depleted, T cells in asymptomatic HIV-infected individuals are functionally abnormal. These T cells are programmed for death, are nonresponsive and fail to produce interleukin-2 after antigenic stimulation. Our view is that these different T-cell abnormalities are explained by the effects of HIV on antigen-presenting cells. Alteration of the functions of the antigen-presenting cell may program T cells for activation-induced death, and may induce anergy in interleukin-2 and interferon-gamma secreting T(H)1 cells. This results in predominance of T(H)2 allergic responses instead of cellular immunity dependent on T(H)1 cells.

引用

页码：161 / 164

页数：4

共 65 条

[1]

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[2]

ARMSTRONG JA, 1984, LANCET, V2, P370

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