DNA BREAKAGE BY TANNIC-ACID AND CU(II) - GENERATION OF ACTIVE OXYGEN SPECIES AND BIOLOGICAL-ACTIVITY OF THE REACTION

被引：19

作者：

BHAT, R ^{[1
]}

HADI, SM ^{[1
]}

机构：

[1] ALIGARH MUSLIM UNIV,FO LIFE SCI,DEPT BIOCHEM,ALIGARH 202002,UTTAR PRADESH,INDIA

来源：

MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS | 1994年 / 313卷 / 01期

关键词：

TANNIC ACID; FREE RADICALS; BIOLOGICAL ACTIVITY;

D O I：

10.1016/0165-1161(94)90032-9

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tannic acid was shown to reduce oxygen to superoxide anion. In the presence of Cu(II), the hydroxyl radical and hydrogen peroxide were formed. Strand scission reaction was shown to account for the biological activity of tannic acid as assayed by bacteriophage inactivation. The inactivating activity occurs through the Fenton pathway for free radical production and subsequent DNA cleavage by these radicals.

引用

页码：49 / 55

页数：7

共 17 条

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