OLFACTORY EXPERIENCE MODULATES APOPTOSIS IN THE DEVELOPING OLFACTORY-BULB

被引:94
作者
NAJBAUER, J [1 ]
LEON, M [1 ]
机构
[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717
关键词
APOPTOSIS; CELL DEATH; DEVELOPMENT; OLFACTORY BULB; OLFACTION; PLASTICITY; SENSORY DEPRIVATION;
D O I
10.1016/0006-8993(94)01448-Q
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Early sensory stimulation plays a key role in shaping the structure and function of the developing olfactory system. Here, we provide the first direct evidence for apoptotic cell death in the olfactory bulbs of rat pups during normal development and we also demonstrate that olfactory deprivation by unilateral naris occlusion causes a dramatic increase in apoptotic cell death in the glomerular and granule cell layers of the deprived bulb. The accessory olfactory bulbs displayed a remarkably high basal level of apoptosis but the occluded accessory bulb did not differ in that regard from the control accessory bulb. These results suggest that apoptosis may be an important mechanism by which the olfactory system can adjust its cell numbers in response to sensory stimuli experienced in early life, thereby underlying one form of plasticity in the developing olfactory system.
引用
收藏
页码:245 / 251
页数:7
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