SIGNAL RESPONSIVE CHEMICAL DELIVERY SYSTEMS BY RADIATION TECHNIQUES AND THE USE FOR BRAIN RESEARCH

Signal responsive chemical delivery systems consisting of a biosensor, actuator and reservoir were prepared partly using radiation means. The sensor unit was constructed by immobilization of enzyme or receptor on the ISFET (Ion Sensitive Field Effect Transistor) gate. The actuator and reservoir unit was prepared from an electro-responsive hydrogel (polyelectrolyte) or by lithography-etching of a semiconductor. Controlled release of smell substances and neurotransmitters was investigated using signal responsive chemical delivery systems. Application of the system to brain research was studied by connecting the smell release system with electroencephalogram (EEG) equipment and measuring the effect of smell on alpha and theta waves of EEG under various mental actions. It was found that the controlled release of smell substance affected remarkedly the EEG profiles of mental actions.