THE INFLUENCE OF REPEATED ADMINISTRATION OF PRAZOSIN ON ITS HYPOTENSIVE EFFECT AND ON RENIN RELEASE IN CONSCIOUS DOGS - A COMPARISON WITH URAPIDIL

被引：4

作者：

BECK, A

KRAUPP, O

BACHER, S

SEITELBERGER, R

RABERGER, G

机构：

来源：

BASIC RESEARCH IN CARDIOLOGY | 1984年 / 79卷 / 05期

关键词：

D O I：

10.1007/BF01910487

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of prazosin (0.1, 0.5 and 2.5 mg/kg, p.o.) on blood pressure, heart rate and PRA [plasma renin activity] were investigated after acute and chronic administration in conscious, normotensive dogs. The acute administration of prazosin caused a reduction in both systolic and diastolic blood pressure and an increase in heart rate and PRA. After chronic administration, twice daily for 4 days, tolerance developed, which was not due to persistent counterregulation. On comparison with urapidil, another .alpha.-adrenoceptor antagonist, the hypotensive and counterregulatory response to acute administration were similar with both substances; the development of tolerance to prazosin after chronic administration contrasted with the results with urapidil.

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页码：579 / 587

页数：9

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共 23 条

[1] BLOOD-PRESSURE RESPONSE AND RENIN RELEASE FOLLOWING 4 DAYS OF TREATMENT WITH DIHYDRALAZINE AND URAPIDIL IN CONSCIOUS DOGS [J].

BACHER, S ;

KRAUPP, O ;

BECK, A ;

SEITELBERGER, R ;

RABERGER, G .

CARDIOVASCULAR RESEARCH, 1984, 18 (02) :67-74

[2] EFFECTS OF CLONIDINE, PRAZOSIN AND PHENTOLAMINE ON HEART-RATE AND CORONARY SINUS CATECHOLAMINE CONCENTRATION DURING CARDIOACCELERATOR NERVE-STIMULATION IN SPINAL DOGS [J].

CAVERO, I ;

DENNIS, T ;

LEFEVREBORG, F ;

PERROT, P ;

ROACH, AG ;

SCATTON, B .

BRITISH JOURNAL OF PHARMACOLOGY, 1979, 67 (02) :283-292

[3] PRAZOSIN AND PRESYNAPTIC ALPHA-RECEPTORS IN CARDIO ACCELERATOR NERVE OF DOG [J].

CONSTANTINE, JW ;

WEEKS, RA ;

MCSHANE, WK .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 50 (01) :51-60

[4] PRAZOSIN DOES NOT ALTER CANINE RENIN RELEASE IN RESPONSE TO SYSTEMIC HYPOTENSION OR INTRA-RENAL ISOPRENALINE AND PROSTAGLANDIN-I2 INFUSION [J].

GERBER, JG ;

NIES, AS ;

OLSON, RD .

BRITISH JOURNAL OF PHARMACOLOGY, 1980, 71 (02) :533-537

[5] COMBINED THERAPY WITH VASODILATOR DRUGS AND BETA-ADRENERGIC BLOCKADE IN HYPERTENSION - COMPARATIVE STUDY OF MINOXIDIL AND HYDRALAZINE [J].

GOTTLIEB, TB ;

CHIDSEY, CA ;

KATZ, FH .

CIRCULATION, 1972, 45 (03) :571-&

[6] EFFECTS OF PRAZOSIN AND PHENTOLAMINE ON ARTERIAL-PRESSURE, HEART-RATE, AND RENIN-ACTIVITY - EVIDENCE IN THE CONSCIOUS RAT FOR THE FUNCTIONAL-SIGNIFICANCE OF THE PRESYNAPTIC ALPHA-RECEPTOR [J].

GRAHAM, RM ;

PETTINGER, WA .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1979, 1 (05) :497-502

[7] APPLICATION OF A RADIOIMMUNOASSAY FOR ANGIOTENSIN I TO PHYSIOLOGIC MEASUREMENTS OF PLASMA RENIN ACTIVITY IN NORMAL HUMAN SUBJECTS [J].

HABER, E ;

KOERNER, T ;

PAGE, LB ;

KLIMAN, B ;

PURNODE, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1969, 29 (10) :1349-+

[8] CHANGES IN ALPHA-ADRENOCEPTORS DURING LONG-TERM TREATMENT OF RABBITS WITH PRAZOSIN [J].

HAMILTON, CA ;

REID, JL .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1981, 3 (05) :977-985

[9] EFFECT OF PRAZOSIN ON PRE-SYNAPTIC AND POST-SYNAPTIC ALPHA-RECEPTORS IN PITHED RAT [J].

HUA, ASP ;

MOULDS, RFW .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1978, 5 (05) :525-528

[10] PHYSIOLOGIC EVALUATION OF A NEW ANTIHYPERTENSIVE AGENT - PRAZOSIN HCL [J].

KOSHY, MC ;

MICKLEY, D ;

BOURGOIGNIE, J ;

BLAUFOX, MD .

CIRCULATION, 1977, 55 (03) :533-537