VIRAL ONCOGENESIS - EPSTEIN-BARR-VIRUS

被引：15

作者：

GAFFEY, MJ ^{[1
]}

WEISS, LM ^{[1
]}

机构：

[1] CITY HOPE NATL MED CTR,DIV PATHOL,DUARTE,CA 91010

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 1990年 / 11卷 / 06期

关键词：

Burkitt's lymphoma; Hodgkin's disease; nasopharyngeal carcinoma; non-Hodgkin's lymphoma;

D O I：

10.1016/0196-0709(90)90115-C

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The Epstein-Barr virus (EBV) is a common herpesvirus that has been linked to several human neoplasms. It has been found in over 90% of cases of Burkitt's lymphoma in endemic regions, although only 15% of cases in nonendemic regions show evidence of infection. The virus has been found in malignant lymphomas in immunocompromised states, including the acquired immunodeficiency syndrome, iatrogenic immunosuppression, such as in posttransplantation patients, and congenital immunodeficiencies. Recently, EBV genomes have been found in approximately 25% of cases of Hodgkin's disease, where it has been found in the Reed-Sternberg cells. Epstein-Barr virus genomes are found in over 90% of cases of undifferentiated nasopharyngeal carcinoma. In addition, EBV has been identified in undifferentiated carcinomas in other sites in Asians, such as carcinomas of the parotid in Chinese individuals and Eskimos. © 1990.

引用

页码：375 / 381

页数：7

共 61 条

[1]

Epstein, Achong, Barr, Virus particles in cultured lymphoblasts from Burkitt's lymphoma, Lancet, 1, pp. 702-703, (1964)

[2]

Lennette, Epstein-Barr virus, Manual of Clinical Microbiology, pp. 728-732, (1985)

[3]

Fingeroth, Weiss, Tedder, Et al., Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2, Proc Natl Acad Sci USA, 81, pp. 4510-4514, (1984)

[4]

Lindahl, Adams, Bjursell, Et al., Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line, Journal of Molecular Biology, 102, pp. 511-530, (1976)

[5]

Burkitt, A sarcoma involving the jaws in African children, British Journal of Surgery, 46, pp. 218-223, (1958)

[6]

Rosenberg, National cancer institute sponsored study of classifications of non-Hodgkin's lymphomas. Summary and description of a working formulation for clinical usage, Cancer, 49, pp. 2112-2135, (1982)

[7]

Croce, Nowell, Molecular genetics of human B cell neoplasia, Adv Immunol, 38, pp. 245-274, (1985)

[8]

de-The, Geser, Day, Et al., Epidemiological evidence for a causal relationship between Epstein-Barr virus and Burkitt's lymphoma: Results of the Ugandan prospective study, Nature, 274, pp. 756-761, (1978)

[9]

Lenoir, Role of the virus, chromosomal translocations and cellular oncogenes in the aetiology of Burkitt's lymphoma, The Epstein-Barr Virus: Recent Advances, pp. 183-205, (1986)

[10]

Geser, Lenoir, Anvret, Et al., Epstein-Barr virus markers in a series of Burkitt's lymphomas from the West Nile District Uganda, European Journal of Cancer and Clinical Oncology, 19, pp. 1393-1401, (1983)

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