ADSORPTION OF IMIPRAMINE ONTO ACTIVATED-CHARCOAL AND A CATION-EXCHANGE RESIN IN MACROGOL-ELECTROLYTE SOLUTION

Adsorption of imipramine onto activated charcoal and a cation exchange resin, sodium polystyrene sulfonate were evaluated in macrogol (polyethylene glycol) electrolyte solution (PEG-ELS) and JP XII second medium. The maximum adsorptive capacity of activated charcoal for imipramine was 6 1 0 mg and 372 mg per g of charcoal in PEG-ELS and JP XII second medium, respectively. On the other hand, the maximum adsorptive capacity of sodium polystyrene sulfonate for the drug was 272 mg and 667 mg per g of the resin in PEG-ELS and JP XII second medium, respectively. Adsorption of imipramine onto both adsorbents was greater when macrogol was omitted from PEG-ELS than in PEG-ELS itself. Adsorption of the drug onto activated charcoal was decreased when sodium sulfonate or sodium bicarbonate was omitted from PEG-ELS, whereas that onto sodium polystyrene sulfonate was decreased only when sodium bicarbonate was omitted from PEG-ELS.