ASYMMETRIC-SYNTHESIS OF A KEY 1-ALPHA,25-DIHYDROXY-VITAMIN-D3 RING-A SYNTHON

被引：34

作者：

KABAT, MM

LANGE, M

WOVKULICH, PM

USKOKOVIC, MR

机构：

[1] Roche Research Center, Hoffmann-La Roche Inc., Nutley

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 50期

关键词：

D O I：

10.1016/0040-4039(93)88021-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and highly stereoselective synthesis of the A-ring synthon 4 of 1,25(OH)2-vitamin D3 (1) is described. The aldehyde 12, which was used for an intramolecular ene reaction to form the main framework 18, was obtained by two different asymmetric approaches starting from olefin 6.

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页码：7701 / 7704

页数：4

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