TEMPORAL AND SPATIAL EXPRESSION OF A FOS-LACZ TRANSGENE IN THE DEVELOPING NERVOUS-SYSTEM

被引：34

作者：

SMEYNE, RJ

CURRAN, T

MORGAN, JI

机构：

[1] ROCHE INST MOLEC BIOL,ROCHE RES CTR,DEPT NEUROSCI,NUTLEY,NJ 07110

[2] ROCHE INST MOLEC BIOL,ROCHE RES CTR,DEPT MOLEC ONCOL,NUTLEY,NJ 07110

[3] ROCHE INST MOLEC BIOL,ROCHE RES CTR,DEPT VIROL,NUTLEY,NJ 07110

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 16卷 / 1-2期

关键词：

C-FOS; PROTOONCOGENE; GENE REGULATION; HIPPOCAMPUS; THALAMUS; OLFACTORY BULB;

D O I：

10.1016/0169-328X(92)90206-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A Fos-lacZ transgenic mouse has been described that accurately recapitulates both constitutive and inducible patterns of c-fos expression in adult mice. Here we describe the developmental expression of the transgene in the brain during the early Postnatal period. On the day of birth, expression of the transgene is observed in several discrete regions of the CNS; including the olfactory bulb, hippocampus, retrosplenial cortex, parafascicular nucleus of the thalamus, and several cranial nerve nuclei. In these regions, expression declines to adult levels by three weeks. In other regions of the CNS, expression appeared transiently after P0.

引用

页码：158 / 162

页数：5

共 24 条

[1] LEARNING-INDUCED INCREASE OF IMMEDIATE EARLY GENE MESSENGER-RNA IN THE CHICK FOREBRAIN [J].