CORRELATION OF BIOENERGETIC PARAMETERS WITH CELL-DEATH IN LISTERIA-MONOCYTOGENES CELLS EXPOSED TO NISIN

被引：62

作者：

WINKOWSKI, K ^{[1
]}

BRUNO, MEC ^{[1
]}

MONTVILLE, TJ ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,COOK COLL,NEW JERSEY AGR EXPT STN,DEPT FOOD SCI,NEW BRUNSWICK,NJ 08903

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1994年 / 60卷 / 11期

关键词：

D O I：

10.1128/AEM.60.11.4186-4188.1994

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In Listeria monocytogenes, nisin induced ATP efflux, reduced the intracellular ATP concentration within 1 min, and dissipated the proton motive force within 2 min. Efflux accounted for only 20% of the ATP depletion, suggesting that ATP hydrolysis also occurred. ATP efflux depended on nisin concentration and followed saturation kinetics. These results suggest that nisin breaches the membrane permeability barrier in a manner more consistent with pore formation than with a nonspecific detergent-like membrane destabilization.

引用

页码：4186 / 4188

页数：3

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