SERUM PARAOXONASE POLYMORPHISM IN 3 POPULATIONS OF SOUTHEAST-ASIA

被引：16

作者：

ROY, AC

SAHA, N

TAY, JSH

RATNAM, SS

机构：

[1] NATL UNIV SINGAPORE, DEPT PAEDIAT, DIV GENET, KENT RIDGE, SINGAPORE 0511, SINGAPORE

[2] NATL UNIV SINGAPORE, DEPT OBSTET & GYNAECOL, SINGAPORE 0511, SINGAPORE

来源：

HUMAN HEREDITY | 1991年 / 41卷 / 04期

关键词：

POPULATION GENETICS; ASIA; CHINESE; INDIANS; FILIPINOS; HARDY-WEINBERG EQUILIBRIUM; PARAOXON; PARAOXONASE POLYMORPHISM;

D O I：

10.1159/000154010

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Serum paraoxonase hydrolyzes paraoxon, the principal metabolite of the insecticide parathion. Serum paraoxonase is polymorphic and controlled by two codominant alleles - PON*A and PON*B representing low and high activity, respectively. Three populations of southeast Asia comprising 194 Chinese, 159 Filipinos and 73 Dravidian Indians were investigated for serum paraoxonase polymorphism. The frequency of PON*B was found to be 0.14 in the Chinese, 0.04 in the Filipinos and 0.18 in Dravidian Indians. The distribution of the PON phenotypes was at Hardy-Weinberg equilibrium in all the three populations studied.

引用

页码：265 / 269

页数：5

共 18 条

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