HUMAN PAPILLOMAVIRUS IN BREAST-CANCER

被引：119

作者：

DILONARDO, A

VENUTI, A

MARCANTE, ML

机构：

[1] Lab. of Virology, CRS, Regina Elena Institute for Cancer Research, Rome, 00158

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1992年 / 21卷 / 02期

关键词：

BREAST CANCER; HPV; INSITU HYBRIDIZATION; PCR;

D O I：

10.1007/BF01836955

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and the in situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences by in situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.

引用

收藏

页码：95 / 100

页数：6

相关论文

共 27 条

[1] HUMAN PAPILLOMA-VIRUS DNAS IMMORTALIZE NORMAL HUMAN MAMMARY EPITHELIAL-CELLS AND REDUCE THEIR GROWTH-FACTOR REQUIREMENTS [J].

BAND, V ;

ZAJCHOWSKI, D ;

KULESA, V ;

SAGER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) :463-467

[2] DETECTION AND LOCALIZATION OF HUMAN PAPILLOMAVIRUS DNA IN HUMAN GENITAL CONDYLOMAS BY IN SITU HYBRIDIZATION WITH BIOTINYLATED PROBES [J].

BECKMANN, AM ;

MYERSON, D ;

DALING, JR ;

KIVIAT, NB ;

FENOGLIO, CM ;

MCDOUGALL, JK .

JOURNAL OF MEDICAL VIROLOGY, 1985, 16 (03) :265-273

[3] HUMAN PAPILLOMAVIRUS INFECTION AND ANAL CANCER [J].

BECKMANN, AM ;

DALING, JR ;

SHERMAN, KJ ;

MADEN, C ;

MILLER, BA ;

COATES, RJ ;

KIVIAT, NB ;

MYERSON, D ;

WEISS, NS ;

HISLOP, TG ;

BEAGRIE, M ;

MCDOUGALL, JK .

INTERNATIONAL JOURNAL OF CANCER, 1989, 43 (06) :1042-1049

[4] THE E6-E7 REGION OF HUMAN PAPILLOMAVIRUS TYPE-18 IS SUFFICIENT FOR TRANSFORMATION OF NIH-3T3 AND RAT-1 CELLS [J].

BEDELL, MA ;

JONES, KH ;

LAIMINS, LA .

JOURNAL OF VIROLOGY, 1987, 61 (11) :3635-3640

[5] A NEW TYPE OF PAPILLOMAVIRUS DNA, ITS PRESENCE IN GENITAL CANCER BIOPSIES AND IN CELL-LINES DERIVED FROM CERVICAL-CANCER [J].

BOSHART, M ;

GISSMANN, L ;

IKENBERG, H ;

KLEINHEINZ, A ;

SCHEURLEN, W ;

HAUSEN, HZ .

EMBO JOURNAL, 1984, 3 (05) :1151-1157

[6] LOCALIZATION OF HUMAN PAPILLOMAVIRUS TYPE-16 DNA USING THE POLYMERASE CHAIN-REACTION IN THE CERVIX UTERI OF WOMEN WITH CERVICAL INTRAEPITHELIAL NEOPLASIA [J].

CORNELISSEN, MTE ;

VANDENTWEEL, JG ;

STRUYK, APHB ;

JEBBINK, MF ;

BRIET, M ;

VANDERNOORDAA, J ;

TERSCHEGGET, J .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :2555-2562

[7] SYNTHESIS INVITRO AND APPLICATION OF BIOTINYLATED DNA PROBES FOR HUMAN PAPILLOMA-VIRUS TYPE 16 BY UTILIZING THE POLYMERASE CHAIN-REACTION [J].

DAY, PJR ;

BEVAN, IS ;

GURNEY, SJ ;

YOUNG, LS ;

WALKER, MR .

BIOCHEMICAL JOURNAL, 1990, 267 (01) :119-123

[8] HETEROGENEITY OF THE HUMAN PAPILLOMAVIRUS GROUP [J].

DEVILLIERS, EM .

JOURNAL OF VIROLOGY, 1989, 63 (11) :4898-4903

[9] A PAPILLOMAVIRUS DNA FROM A CERVICAL-CARCINOMA AND ITS PREVALENCE IN CANCER BIOPSY SAMPLES FROM DIFFERENT GEOGRAPHIC REGIONS [J].

DURST, M ;

GISSMANN, L ;

IKENBERG, H ;

ZURHAUSEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12) :3812-3815

[10]

GALLOWAY DA, 1989, ADV VIRUS RES, V37, P125