EFFECT OF BASIC FIBROBLAST GROWTH-FACTOR AND ALPHA-MELANOCYTIC STIMULATING HORMONE ON NERVE REGENERATION THROUGH A COLLAGEN CHANNEL

被引：57

作者：

LAQUERRIERE, A

PEULVE, P

JIN, O

TIOLLIER, J

TARDY, M

VAUDRY, H

HEMET, J

TADIE, M

机构：

[1] Pathology Laboratory, Charles Nicolle Hospital, Rouen

[2] Experimental Neurosurgery Laboratory, UER de Médecine, Rouvray

[3] IMEDEX, Chaponost

[4] European Institute for Peptide Research, Laboratory of Molecular Endocrinology, CNRS URA, UA INSERM, University of Rouen-Mont Saint Aignan

来源：

MICROSURGERY | 1994年 / 15卷 / 03期

关键词：

D O I：

10.1002/micr.1920150312

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

An experimental study on the rat sciatic nerve was performed to evaluate nerve regeneration through a collagen guide and to study the effects of alpha-melanocytic stimulating hormone (alpha-MSH) and basic fibroblast growth factor (b-FGF) in accelerating axonal elongation. After transection, nerves were repaired over a 7 mm gap using a placental collagen type IV guide. The channel was filled with either a b-FGF solution or an alpha-MSH solution or was produced with b-FGF incorporated into the guide. Four weeks later, only groups in which b-FGF had been injected or incorporated displayed a significant somatosensory evoked potential response. Histological and quantitative analysis of nerve fibres confirmed the existence of nerve continuity in groups receiving an alpha-MSH solution or a channel containing b-FGF. These results demonstrate that alpha-MSH in solution and b-FGF incorporated into a collagen type IV channel enhance peripheral nerve regeneration. However, at 4 weeks, only b-FGF (3 ng) restores functional activity. (C) 1994 Wiley-Liss, Inc.

引用

页码：203 / 210

页数：8

共 27 条

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