STUDY OF THE RELEASE MECHANISM OF CARTEOLOL INERT MATRIX TABLETS ON THE BASIS OF PERCOLATION THEORY

被引：16

作者：

CARABALLO, I ^{[1
]}

FERNANDEZAREVALO, M ^{[1
]}

HOLGADO, MA ^{[1
]}

RABASCO, AM ^{[1
]}

LEUENBERGER, H ^{[1
]}

机构：

[1] UNIV BASEL,SCH PHARM,CH-4051 BASEL,SWITZERLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 109卷 / 03期

关键词：

PERCOLATION THEORY; PERCOLATION THRESHOLD; CONTROLLED RELEASE; RELEASE MECHANISM; ZERO-ORDER PERIOD; INERT MATRIX TABLET; CARTEOLOL HYDROCHLORIDE;

D O I：

10.1016/0378-5173(94)90385-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present paper, percolation theory has been applied to the study of the release mechanism obtained from controlled release tablets of carteolol hydrochloride. These dosage systems had already been studied on the basis of 'classical' theories. The new approach to this study has allowed us to obtain more complete information about the release of these inert matrix systems. The results obtained in this study demonstrate that percolation theory can provide useful parameters that can be considered as important tools for the proper design of these controlled release dosage forms.

引用

页码：229 / 236

页数：8

共 19 条

[1]

AIACHE JM, 1982, BIOFARMACIA, P308

[2]

BONNY JD, 1991, PHARM ACTA HELV, V66, P160

[3] PERCOLATION THEORY - APPLICATION TO THE STUDY OF THE RELEASE BEHAVIOR FROM INERT MATRIX SYSTEMS [J].