LIQUID ORAL MAGNETIC PARTICLES AS A GASTROINTESTINAL CONTRAST AGENT FOR MR IMAGING - EFFICACY INVIVO

被引：14

作者：

RUBIN, DL ^{[1
]}

MULLER, HH ^{[1
]}

SIDHU, MK ^{[1
]}

YOUNG, SW ^{[1
]}

HUNKE, WA ^{[1
]}

GORMAN, WG ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT DIAGNOST RADIOL,RM S-074,STANFORD,CA 94305

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 01期

关键词：

CONTRAST ENHANCEMENT; CONTRAST MEDIA; GASTROINTESTINAL TRACT; MR; IRON;

D O I：

10.1002/jmri.1880030119

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Recent in vitro studies suggested there is an optimal range of concentration and viscosity for a liquid formulation of oral magnetic particles (WIN 39996) for magnetic resonance (MR) imaging of the gastrointestinal (GI) tract. To determine whether this formulation is also effective in vivo and whether differing viscosity and administration regimen affect GI distribution of the contrast agent, a range of concentrations of iron (75, 150, and 200 mug/mL) and viscosities (1, 150, and 600 cp) were imaged in dogs at 1.5 T with conventional spin-echo and fat-saturation pulse sequences. The effects of dose regimen (single vs divided dose) and subject position (supine vs right lateral decubitus) were also studied. The 75 and 200 mug/mL concentrations were unacceptable for MR imaging, while 150 mug/mL was effective. The GI distribution of the contrast agent was affected jointly by viscosity, subject position, and dose regimen. The 150 mug/mL formulation produced excellent GI contrast enhancement in vivo for both 150- and 600-cp viscosities. The choice of optimal viscosity may depend on the preferred administration regimen.

引用

页码：113 / 118

页数：6

共 8 条

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