OXYGEN-FREE RADICALS AND ACUTE-PANCREATITIS - FACT OR FICTION

被引:5
作者
CREAGH, TA [1 ]
LEAHY, AL [1 ]
BOUCHIERHAYES, DJ [1 ]
TORMEY, W [1 ]
LEADER, M [1 ]
BROE, PJ [1 ]
机构
[1] BEAUMONT HOSP,DEPT SURG,DUBLIN 9,IRELAND
关键词
D O I
10.1007/BF03022581
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of oxygen free radical suppression was studied in the taurocholate model of acute pancreatitis in the rat using systemic allopurinol, superoxide dismutase (S.O.D.) and catalase. None of the treatments were beneficial which suggests that oxygen free radical suppression is unlikely to be clinically beneficial in acute pancreatitis.
引用
收藏
页码:497 / 498
页数:2
相关论文
共 14 条
[1]  
Broe P.J., Cameron J.L., Experimental gallstone pancreatitis: pathogeneis and response to different treatment modalities, Ann. Surg., 195, 5, pp. 566-573, (1982)
[2]  
Sanfey H., Bulkley G.B., Cameron J.L., The pathogenesis of acute pancreatitis. The source and role of oxygen derived free radicals in three different experimental models, Ann. Surg., 201, pp. 635-639, (1985)
[3]  
Guice K.S., Miller D.E., Oldham K.T., Townsend C.M., Thompson J.C., Superoxide dismutase and catalase
[4]  
a possible role in established pancreatitis, Am. J. Surg, 151, pp. 163-169, (1986)
[5]  
Aho A.J., Koskensalo S.M., Nevalainen T.J., Experimental pancreatitis in the rat, Scand. J. Gastroenterol., 15, pp. 411-416, (1980)
[6]  
Brown V., Friderick I., Superoxide radical and superoxide dismutases: threat and defence, Acta. Physiol. Scand., 15, pp. 411-416, (1980)
[7]  
Bulkley G.B., Pathophysiology of free radical mediated reperfusion injury, J. Vase. Surg., 5, pp. 512-17, (1987)
[8]  
Sanfey H., Sarr M.G., Bulkley G.B., Cameron J.L., Oxygen derived free radicals and acute pancreatitis: a review, Acta. Physiol. Scand., 548, pp. 109-118, (1986)
[9]  
Boveris A., Cadenas E., Reiter R., Filipowsky M., Nakase V., Chance B., Organ chemiluminescence: non invasive assay for oxidati ve radical reactions, Proc. Natl. Acad. Sci. USA, 77, pp. 347-351, (1980)
[10]  
Gough D.B., Boyle B., Joyce W.P., Delaney C.P., McGeeney C.P., Gorey T.F., Fitzpatrick J.M., Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis, Br. J. Surg., 77, pp. 1256-1259, (1990)