INDUCED CERVICAL RIPENING WITH MIFEPRISTONE (RU 486) AND BIOCONVERSION OF ARACHIDONIC-ACID IN HUMAN PREGNANT UTERINE CERVIX IN THE 1ST TRIMESTER - A DOUBLE-BLIND, RANDOMIZED, BIOMECHANICAL AND BIOCHEMICAL-STUDY

被引：40

作者：

RADESTAD, A ^{[1
]}

BYGDEMAN, M ^{[1
]}

GREEN, K ^{[1
]}

机构：

[1] KAROLINSKA HOSP, DEPT CLIN CHEM, S-10401 STOCKHOLM 60, SWEDEN

来源：

CONTRACEPTION | 1990年 / 41卷 / 03期

关键词：

D O I：

10.1016/0010-7824(90)90069-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The effect of mifepristone on the uterine cervix was studied in 55 nulliparae at 7 to 10 weeks gestation, wishing to undergo a vacuum aspiration. The patients were randomly assigned to three groups which received preoperative drug or placebo treatment starting 36 or 48 hours before surgery. Cervical biopsies from 12 of the subjects were used in a double-blind test to study the bioconversion of 14C-labeled arachidonic acid. By using an objective method to study the cervical resistance to dilatation,it was shown that the cervix was significantly less (p < 0.05) resistant to dilatation after pretreatment with mifepristone compared to placebo. The longer treatment was significantly (p < 0.05) more effective than the shorter. No significant difference of the 14C-arachidonic acid bioconversion was demonstrated. © 1990.

引用

页码：283 / 292

页数：10

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