REVIEW OF THE GENOTOXICITY AND CARCINOGENICITY OF 4,4'-METHYLENE-DIANILINE AND 4,4'-METHYLENE-BIS-2-CHLOROANILINE

被引:48
作者
MCQUEEN, CA
WILLIAMS, GM
机构
[1] American Health Foundation, Valhalla, NY 10595, One Dana Road
来源
MUTATION RESEARCH | 1990年 / 239卷 / 02期
关键词
4,4′-Methylene-bis-2-chloroaniline; 4,4′-Methylene-dianiline; Polycyclic aromatic amines;
D O I
10.1016/0165-1110(90)90034-9
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
4,4′-Methylene-dianiline (MDA) and 4,4′-methylene-bis-2-chloroaniline (MOCA) are polycyclic aromatic amines that are currently used in industry. Both compounds have been found to be bacterial mutagens and to be positive in a number of assays for genotoxicity. In animal studies, MDA has induced thyroid and liver neoplasms while exposure to MOCA resulted in a variet of tumors including those of the liver, mammary gland and bladder. Epidemiologic proof of human carcinogenicity of both compounds is lacking; however, there is evidence that MOCA can be metabolized to mutagenic products by human tissue. In this paper, the major findings concerning the biotransformation, genotoxicity and carcinogenicity of MDA and MOCA are reviewed. © 1990.
引用
收藏
页码:133 / 142
页数:10
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