DEMONSTRATION OF MISMATCH NEGATIVITY IN THE MONKEY

被引：138

作者：

JAVITT, DC

SCHROEDER, CE

STEINSCHNEIDER, M

AREZZO, JC

VAUGHAN, HG

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

[3] BRONX PSYCHIAT CTR,BRONX,NY 10461

来源：

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1992年 / 83卷 / 01期

关键词：

EVENT-RELATED POTENTIALS; AUDITORY; COGNITIVE; ODDBALL; P300;

D O I：

10.1016/0013-4694(92)90137-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.

引用

页码：87 / 90

页数：4

共 14 条

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