CHANGES IN CHROMATIN STRUCTURE DUE TO HYPOMETHYLATION INDUCED WITH 5-AZACYTIDINE OR DL-ETHIONINE

被引：26

作者：

FAJKUS, J ^{[1
]}

VYSKOT, B ^{[1
]}

BEZDEK, M ^{[1
]}

机构：

[1] CZECHOSLOVAK ACAD SCI, INST BIOPHYS, KRALOVOPOLSKA 135, CS-61265 BRNO, CZECHOSLOVAKIA

来源：

FEBS LETTERS | 1992年 / 314卷 / 01期

关键词：

DNA METHYLATION; NUCLEOSOME POSITIONING; REPETITIVE DNA SEQUENCE; TOBACCO TISSUE CULTURE;

D O I：

10.1016/0014-5793(92)81449-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Changes in chromatin structure of the HRS60 family of repetitive sequences in tobacco DNA were studied after hypomethylation induced with 5-azacytidine or DL-ethionine. The TaqI site in the HRS60 units lies in nucleosomal core regions and its cleavage is enhanced in the hypomethylated chromatin. In contrast, the cleavage of the Sau3AI site located in linker DNA does not depend on the level of methylation of DNA.

引用

页码：13 / 16

页数：4

共 15 条

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