TRANSCRIPTION FACTOR PIT-1 AND ITS CLINICAL IMPLICATIONS - FROM BENCH TO BEDSIDE

被引：5

作者：

HAUGEN, BR ^{[1
]}

RIDGWAY, EC ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV ENDOCRINOL DIABET & METAB,DENVER,CO 80262

来源：

ENDOCRINOLOGIST | 1995年 / 5卷 / 02期

关键词：

D O I：

10.1097/00019616-199503000-00009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review presents a transcription factor, Pit I, and its relevance to clinical practice. Our knowledge of the molecular and genetic basis of disease is growing at an amazing pace. Intranuclear transcription factor proteins, which influence gene expression, are being discovered and characterized. Pit-1, a pituitary-specific transcription factor, is necessary for the development and subsequent function of somatotrophs, lactotrophs, and thyrotrophs of the anterior pituitary gland. In this review we will discuss the molecular mechanisms by which Pit-1 influences gene expression and explore the role of this factor in pituitary diseases such as hypopituitarism and pituitary tumors.

引用

页码：132 / 139

页数：8

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