SYNTHESIS OF PYRROLO[2,1-C][1,4]BENZODIAZEPINES VIA AN INTRAMOLECULAR AZA-WITTIG REACTION - SYNTHESIS OF THE ANTIBIOTIC DC-81

被引：93

作者：

MOLINA, P

DIAZ, I

TARRAGA, A

机构：

[1] Departamento de Química Orgánica, Facultad de Químicas, E-30071 Murcia, Universidad Murcia Campus Espinardo

来源：

TETRAHEDRON | 1995年 / 51卷 / 19期

关键词：

D O I：

10.1016/0040-4020(95)00222-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient synthesis of the pyrrolo[2,1-c][1,4]benzodiazepine ring system has been carried out using, as a key step, an intramolecular aza Wittig reaction of the appropriately substituted N-(2-azidobenzoyl)pyrrolidine-2-carboxaldehydes. The parent unsubstituted PBD 4 and the natural product DC-81 have been prepared in the imine form in good overall yields.

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页码：5617 / 5630

页数：14

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