FOLATE ANTAGONISTS .20. SYNTHESIS AND ANTI-TUMOR AND ANTI-MALARIAL PROPERTIES OF TRIMETREXATE AND RELATED 6-[(PHENYLAMINO)METHYL]-2,4-QUINAZOLINEDIAMINES

被引：79

作者：

ELSLAGER, EF ^{[1
]}

JOHNSON, JL ^{[1
]}

WERBEL, LM ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PHARMACEUT RES,DEPT CHEM,ANN ARBOR,MI 48105

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1983年 / 26卷 / 12期

关键词：

D O I：

10.1021/jm00366a018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1753 / 1760

页数：8

共 25 条

[1] 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXYANILINO)METHYL]QUINAZOLINE (TMQ), A POTENT NON-CLASSICAL FOLATE ANTAGONIST INHIBITOR .1. EFFECT ON DIHYDROFOLATE-REDUCTASE AND GROWTH OF RODENT TUMORS INVITRO AND INVIVO
BERTINO, JR
SAWICKI, WL
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CASHMORE, AR
ELSLAGER, EF
[J]. BIOCHEMICAL PHARMACOLOGY, 1979, 28 (12) : 1983 - 1987
[2] BIRD OD, 1970, MOL PHARMACOL, V6, P573
[3] CARLIN SC, 1974, MOL PHARMACOL, V10, P194
[4] DAVIDSON DE, COMMUNICATION
[5] ANTIMALARIAL DRUGS .24. FOLATE ANTAGONISTS .2. 2,4-DIAMINO-6-[[ARALKYL AND (HETEROCYCLIC)METHYL]AMINO]QUINAZOLINES, A NOVEL CLASS OF ANTIMETABOLITES OF INTEREST IN DRUG-RESISTANT MALARIA AND CHAGAS-DISEASE
DAVOLL, J
DAVIES, HJ
CLARKE, J
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JOHNSON, AM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (08) : 812 - &
[6] QUINAZOLINE ANALOGUES OF FOLIC ACID
DAVOLL, J
JOHNSON, AM
[J]. JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1970, (08): : 997 - &
[7] DIDDENS H, UNPUB CANCER RES
[8] ANTI-MALARIAL DRUGS .44. FOLATE ANTAGONISTS .15. 2,4-DIAMINO-6-(2-NAPHTHYLSULFONYL)QUINAZOLINE AND RELATED 2,4-DIAMINO-6-[(PHENYL AND NAPHTHYL)SULFINYL AND SULFONYL]QUINAZOLINES, A POTENT NEW CLASS OF ANTI-METABOLITES WITH PHENOMENAL ANTI-MALARIAL ACTIVIT
ELSLAGER, EF
HUTT, MP
JACOB, P
JOHNSON, J
TEMPORELLI, B
WERBEL, LM
WORTH, DF
RANE, L
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (10) : 1247 - 1257
[9] ANTIMALARIAL DRUGS .31. FOLATE ANTAGONIST .9. 2,4-DIAMINO-6-[(ARALKY)ALKYLAMINO] QUINAZOLINES, A POTENT CLASS OF ANTIMETABOLITES WITH PREPRODIGIOUS ANTIMALARIAL EFFECTS
ELSLAGER, EF
BIRD, OD
DAVOLL, J
CLARKE, J
WORTH, DF
PERRICONE, SC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (11) : 1138 - +
[10] ELSLAGER EF, 1974, LECTURES HETEROCYCLI, V2, pS97

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