ANALYSIS OF A NEURONAL ANTIGEN (HU) EXPRESSION IN THE DEVELOPING RAT-BRAIN DETECTED BY AUTOANTIBODIES FROM PATIENTS WITH PARANEOPLASTIC ENCEPHALOMYELITIS

被引：41

作者：

GRAUS, F ^{[1
]}

FERRER, I ^{[1
]}

机构：

[1] HOSP LLOBREGAT,HOSP PRINCIPES ESPANA,DEPT PATHOL,NEUROPATHOL UNIT,BARCELONA,SPAIN

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 01期

关键词：

Autoantibody; Immunohistochemistry; Neuronal differentiation; Paraneoplastic disease;

D O I：

10.1016/0304-3940(90)90314-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Anti-Hu is an autoantibody that recognizes an antigen (Hu) highly restricted to neuronal nuclei. In the developing rat brain all neurons and the germinal cell layer were anti-Hu positive. Ependyma and choroid plexus were positive only in the early stages of development. The strongest expression of Hu was seen in the most mature neurons. The transitory nature of Cajal-Retizus and subplate neurons was confirmed with the anti-Hu staining. Although the Hu is also expressed by neural cells other than neurons, the strongest staining of mature neurons could indicate that Hu plays a role in the process of neuronal differentiation. © 1990.

引用

页码：14 / 18

页数：5

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