GLYCERYLPHOSPHOCHOLINE PHOSPHOCHOLINE PHOSPHODIESTERASE ACTIVITY IS REDUCED IN MULTIPLE-SCLEROSIS PLAQUES

被引：19

作者：

JANZEN, L

TOURTELLOTTE, WW

KANFER, JN

机构：

[1] REED NEUROL RES CTR,DEPT NEUROL,LOS ANGELES,CA 90024

[2] VET ADM WADSWORTH MED CTR,NEUROL SERV,LOS ANGELES,CA 90073

[3] VET ADM WADSWORTH MED CTR,RES SERV,LOS ANGELES,CA 90073

来源：

EXPERIMENTAL NEUROLOGY | 1990年 / 109卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0014-4886(90)90079-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glycerylphosphorylcholine (GPC) phosphocholine phosphodiesterase activity (EC 3.1.4.38) is significantly reduced in multiple sclerosis plaques compared to adjacent tissue with a P < 0.01 based upon the Student-Newman-Keuls or Tukey test. This finding is in accord with the proposal that this particular form of the enzyme is myelin-specific. Similar activities for GPC phosphocholine phosphodiesterase were obtained with samples from various regions of the same individual brain. © 1990.

引用

页码：243 / 246

页数：4

共 15 条

[1] SOME CHARACTERISTICS OF SN-GLYCERO-3-PHOSPHOCHOLINE DIESTERASES FROM RAT-BRAIN [J].