ANTIDIARRHEIC ACTIVITY OF SCLEROCARYA-BIRREA BARK EXTRACT AND ITS ACTIVE TANNIN CONSTITUENT IN RATS

被引：44

作者：

GALVEZ, J ^{[1
]}

ZARZUELO, A ^{[1
]}

CRESPO, ME ^{[1
]}

UTRILLA, MP ^{[1
]}

JIMENEZ, J ^{[1
]}

SPIESSENS, C ^{[1
]}

DEWITTE, P ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,PHARMACEUT BIOL & PHYTOPHARMACOL LAB,B-3000 LOUVAIN,BELGIUM

来源：

PHYTOTHERAPY RESEARCH | 1991年 / 5卷 / 06期

关键词：

SCLEROCARYA-BIRREA; ANTIDIARRHEIC ACTIVITY; TANNIN; LAXATIVE;

D O I：

10.1002/ptr.2650050611

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antidiarrhoeic activity of the bark of Sclerocarya birrea was investigated. The lyophilized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by magnesium sulphate and sodium picosulphate. This antidiarrhoeic activity was related to an inhibition of intestinal transit rather than to inhibition of net secretion of fluid and electrolytes provoked by the laxative agents. A condensed tannin was isolated from the crude drug which produced inhibition in intestinal motility, and the monomer of which was identified as procyanidin.

引用

页码：276 / 278

页数：3

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