THYROID-HORMONE REGULATION OF MITOCHONDRIAL-FUNCTION - COMMENTS ON THE MECHANISM OF SIGNAL TRANSDUCTION

被引：56

作者：

NELSON, BD

机构：

[1] Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Stockholm

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1018卷 / 2-3期

关键词：

Hormone regulation; Mitochondrial function; Signal transduction; Thyroid hormone; Triiodothyronine;

D O I：

10.1016/0005-2728(90)90266-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thyroid hormone exerts two types of effect on mitochondria. The first of these is a rapid activation of respiration which takes place within minutes after hormone injection, and is preserved in isolated mitochondria. The second response occurs after 1 to several days of injection and leads to mitochondrial biogenesis and increases in mitochondria mass. The hormone signal for these two responses involves either triiodothyronine (T3)-responsive nuclear genes or a direct action of T3 at mitochondria binding sites. © 1990.

引用

页码：275 / 277

页数：3

共 24 条

[1]

Barsano C. P., 1983, MOL BASIS THYROID HO, P139

[2] CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY-CHAIN IN MITOCHONDRIA AND CELLS [J].