DNA-DAMAGE AND THE DNA-ACTIVATED PROTEIN-KINASE

被引：241

作者：

ANDERSON, CW

机构：

[1] C.W. Anderson is at the Biology Department, Brookhaven National Laboratory, Upton

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 11期

关键词：

D O I：

10.1016/0968-0004(93)90144-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that is activated in vitro by DNA fragments. The cellular targets of DNA-PK are nuclear, DNA-binding, regulatory proteins including Sp1, Fos, Jun, Myc, the tumor suppressor protein p53, and RNA polymerase II. These characteristics suggest a role for DNA-PK in coordinating nuclear processes and as a modulator of checkpoint mechanisms activated by DNA damage.

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页码：433 / 437

页数：5

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